#

#	BTA	Position	Gene expression		Mammary-	Cluster	Gene identifier		Co-localized bovine QTL⁶
	Mbp		Mammary	GeneAtlas²	specific expression³	expression profile⁴	Human	Cattle	QTL viewer	QTL Map⁷
1	1	3-6	93146_at	CLDN8	***	1,1,2,1	NM_199328	538761 ⁵
2	(103)	10-11	96146_at	BTG3	*	1,1,2,1	NM_006806	541054		·
3		25	96953_at	CXCL14		1,1,1,2	NM_004887	511771
4		43	93592_at	APOD		1,1,1,2	NM_001647	613972		·
5		51	94431_at	ST6GAL1		1,1,2,1	NM_173216	282073	BTA 1
6		51-57	93949_at	GNB4		1,1,2,1	NM_021629	525962 ⁵		·
7		74	95708_at	SERP1	*	1,1,2,1	NM_014445	528100
8		76	92851_at	CP	**	1,1,1,2	NM_000096	514194		·
9		81	104716_at	RBP1		1,2,1,1	NM_002899	537379
10		82	161075_at	FAM62C		0,1,2,1	NM_031913	526280		·
11		93	92637_at	PFKL		1,1,2,1	NM_001002021	508683
12	2	5	104386_f_at	ITGAV		0,1,2,1	NM_002210	281875		·
13	(87)	26	104257_g_at	PSCDBP	***	1,2,2,1	NM_004288	540450		·
14		69	100600_at	CD24	*	1,2,2,1	NM_013230	NW_930970	BTA 2
15		75	94214_at	FABP3	***	1,2,2,1	NM_004102	281758		·
16		79	97909_at	STMN1		1,2,1,1	NM_005563	616317
17	3	3	94367_at	UCK2		1,2,2,1	NM_012474	541028
18	(85)	4	99481_at	ATP1A2		2,1,0,1	NM_000702	515161		··
19		4	102426_at	CASQ1		2,1,0,1	NM_001231	508394
20		9	102918_at	MUC1	**	0,1,2,1	NM_002456	281333
21		9	97269_f_at	KRTCAP2		0,1,2,1	NM_173852	540389
22		9	99098_at	FDPS		1,1,2,1	NM_002004	281156		··
23		9	102960_at	RAG1AP1	*	1,1,2,1	NM_018845	520463
24		10	101061_at	SSR2	*	1,2,2,1	NM_003145	506530	BTA 3
25		11	100127_at	CRABP2	*	1,2,1,1	NM_001878	493998
26		16	98543_at	CTSS		1,1,1,2	NM_004079	327711		·
27		22	104477_at	FAM46C		0,1,2,1	NM_017709	517961
28		35	103421_at	FRRS1		0,1,2,1	NM_001013660	516522 ⁵
29		42-45	161677_r_at	GBP6		1,1,2,1	NM_198460	513659 ⁵
30		47	103389_at	AASS	**	0,1,2,1	NM_005763	520865		·
31		71	95642_at	ELOVL1	*	1,2,2,1	NM_022821	540348
32	4	0.75	100949_at	FAM20C	**	1,2,2,1	NM_020223	534672		·
33	(70)	22	96591_at	RELN		1,2,1,1	NM_005045	281450	BTA 4	·
34		26	97964_at	FKBP11		1,2,2,1	NM_016594	506043		·
35		50	98443_at	LEP		1,1,1,2	NM_000230	280836
36	5	1	160829_at	PHLDA1		1,2,1,1	NM_007350	540135
37	(76)	4	92608_at	CSRP1		1,2,1,1	NM_004078	539381
38		7	97442_at	SLC39A8	**	0,1,2,1	NM_022154	540512		·
39		16	98063_at	Glycam1	***	1,2,2,1	NM_008134	282430
40		26	92994_at	LALBA	***	0,1,2,1	NM_002289	281894
41		29	95539_at	RAB3IP		1,1,2,1	NM_001024647	533284		·
42		33	92541_at	MYL1	**	2,1,0,1	NM_079420	281341	BTA 5
43		33	103002_at	B4GALT1	*	1,1,2,1	NM_001497	614365
44		44	161758_r_at	RBM9		1,1,2,1	NM_001031695	514951		·
45		49-50	104262_at	PTHLH		1,1,2,1	NM_002820	286767
46		57	93866_s_at	MGP		1,1,1,2	NM_000900	282660
47		60	95661_at	CD9	*	1,2,1,1	NM_001769	280746
48		69	97811_at	ARFGAP3	**	1,1,2,1	NM_014570	532778		··
49		75	93207_at	ACR		1,1,2,1	NM_001097	280711
50	6	0.02	100463_at	Csng	***	0,1,2,1	NM_007785	282209		··
51	(70)	0.02	98814_at	Csnd	***	1,1,2,1	NM_009973	282209
52		2-5	102774_at	EGF		1,1,2,1	NM_001963	518948 ⁵		···
53		3	104343_f_at	PLA2G12A		1,2,2,1	NM_030821	527214	BTA 6
54		15	93626_at	ABCG2	***	1,1,2,1	NM_004827	505219		···
55		22	98994_at	Slc34a2	***	1,2,2,1	NM_006424	282484
56		39	160549_at	TPARL	**	1,1,2,1	NM_018475	532600		···
57		45	99065_at	Csnk	***	0,1,2,1	NM_005212	281728
58	7	11	102343_at	CD320		1,2,2,1	NM_016579	505043		·
59	(69)	15	96318_at¹	C19orf10		1,2,2,1	NM_019107	407769		·
60		16	94753_at	GNA15		1,1,2,1	NM_002068	532029 ⁵	BTA 7	·
61		58-63	103891_i_at	ELL2	**	1,1,2,1	NM_012081	527529 ⁵		··
62	8	4	93351_at	HPGD		1,1,1,2	NM_000860	512259		·
63	(62)	7-8	161294_f_at	CLU	*	0,1,2,1	NM_001831	280750
64		14	98589_at	ADFP	***	0,1,2,1	NM_001122	280981 ⁵	BTA 8	·
65		17-18	94319_at	RAB18		1,1,2,1	NM_021252	511160
66		19	95603_at	GLDC	***	1,1,2,1	NM_000170	507688
67		33	104147_at	NANS		1,2,2,1	NM_018946	540602
68	9	12	93843_at	DHRS1		1,1,2,1	NM_138452	528832
69	(65)	12-15	101446_at	TPD52L1	*	0,1,2,1	NM_001003396	534629 ⁵
70		21	104198_at	CDCP1	**	1,2,2,1	NM_022842	540622	BTA 9	·
71		44-45	101973_at	CITED2		0,1,2,1	NM_006079	521378 ⁵		···
72		59	102813_f_at	UBE1DC1		1,1,2,1	NM_024818	509292		·
73	10	0.03	94294_at	CCNB2		1,2,1,1	NM_004701	281668		·
74	(70)	25	162011_f_at	RHOU	*	0,1,2,1	NM_021205	538143
75		36	101889_s_at	RORA	*	1,1,2,1	NM_002943	535597	BTA 10	·
76		53	98473_at	ARG2	**	1,1,2,1	NM_001172	518752		·
77		60	103581_at	ACOT2		1,2,1,1	NM_006821	511033		·
78	11	49-12	97950_at	XDH	***	0,1,2,1	NM_000379	280960 ⁵
79	(87)	24	97451_at	MCFD2		1,1,2,1	NM_139279	507787		·
80		30	93195_at	MFHAS1		0,1,2,1	NM_004225	527341
81		41	100943_at	SLC1A4	*	0,1,2,1	NM_003038	326577
82		42	92882_at	RAB1A		1,1,2,1	NM_004161	540685	BTA 11	·
83		54	162404_i_at	MGC16372		1,1,2,1	NM_145038	509524
84		69	96144_at	ID4		1,2,1,1	NM_001546	505025
85		72	101665_at	NR5A1		1,1,2,1	NM_004959	281948		·
86		77	160564_at	LCN2	***	0,1,2,1	NM_005564	526639
87		77	96709_at	C9orf16		1,1,2,1	NM_024112	616015
88		78	100054_s_at	C9orf114		0,1,2,1	NM_016390	327707
89		80	95505_at	TOR1B		1,1,2,1	NM_014506	533928		·
90		83	99939_at	CEL	***	0,1,2,1	NM_001807	280748
91	12	4	93416_at	TNFSF11		1,2,1,1	NM_003701	513836		·
92	(49)	12	94931_at	UFM1		1,1,2,1	NM_016617	530547		·
93		19-20	102571_at	GJB6	***	1,2,1,1	NM_006783	508454	BTA 12	·
94		20	98423_at	GJB2	***	1,2,1,1	NM_004004	508454		·
95		40-46	160608_at	RAB20		1,2,2,1	NM_017817	615760 ⁵
96	13	28	160921_at	ACSS1	*	1,2,2,1	NM_032501	282873		·
97	(63)	40	92275_at	TFAP2C		1,2,1,1	NM_003222	511317
98		41	103343_at	5430432M24	*	1,2,2,1	NM_146127	540118	BTA 13	·
99		55	161650_at	SLPI		1,1,1,2	NM_003064	616016		·
100	14	2	97525_at	GK		1,2,2,1	NM_000167	538702
101	(51)	3	96596_at	NDRG1	*	0,1,2,1	NM_006096	504499
102		3	96201_at	GPR172B		1,1,2,1	NM_017986	527884		···
103		3	97789_at	FOXH1		1,1,2,1	NM_003923	493733	BTA 14
104		19-21	98956_at¹	TRAM1		1,1,2,1	NM_014294	281546 ⁵		·
105		36-37	101002_at	AZIN1		1,1,2,1	NM_015878	532835
106		42	160702_at	RBM35A		1,2,2,1	NM_017697	538640
107		46	92642_at	CA2		1,2,1,1	NM_000067	280740		·
108	15	1	95339_r_at	MMP12		1,1,1,2	NM_002426	526981
109	(54)	9	93541_at	TAGLN		1,2,1,1	NM_001001522	513463
110		14	94827_at	FXYD2		1,1,1,2	NM_021603	281773
111		22	102197_at	NUCB2	***	1,1,2,1	NM_005013	509003
112		26	161600_r_at	SH2BP1		1,1,2,1	NM_014633	534265
113		29	93785_at	FOLR1	***	0,1,2,1	NM_016725	516067	BTA 15
114		31	101869_s_at	HBB		1,2,2,1	NM_000518	280813
115		33	96735_at	STARD10		1,2,2,1	NM_006645	514624
116		40	161888_r_at	COMMD9	*	1,1,2,1	NM_014186	510280		·
117		46	99584_at	CD82(Kai1)	*	1,1,2,1	NM_001024844	506713
118	16	1	93479_at	MFSD4	*	0,1,2,1	NM_181644	515128
119	(57)	3	99926_at	PIGR	***	0,1,2,1	NM_002644	281401		·
120		17	160339_at	PYCR2		1,1,2,1	NM_013328	504987 ⁵
121		22	100028_r_at	PEX14		1,1,2,1	NM_004565	507393
122		41	96603_at	QSCN6	*	1,1,2,1	NM_002826	NW_929089	BTA 16	·
123		48	104114_at	EDEM3		1,2,2,1	NM_025191	535395
124		50	161188_f_at	LAMB3	**	1,2,1,1	NM_000228	529939		·
125		50	97531_at	G0s2	***	1,2,2,1	NM_015714	507436
126	17 (46)	42	93736_at	TCN2		1,1,2,1	NM_000355	281518	BTA 17	··
127	18	13	104221_at	SLC7A5	*	1,2,2,1	NM_003486	282369
128	(57)	14	161474_r_at	DPEP3		0,1,2,1	NM_022357	618258
129		25	99409_at	SLC6A2		1,1,2,1	NM_001043	282363		·
130		36	98485_at	RHPN2	**	1,2,2,1	NM_033103	533687
131		41	104255_at	FHOD3		1,1,1,2	NM_025135	505697
132		41	103846_at	LGALS7		1,2,1,1	NM_002307	505697
133		43-45	162286_r_at	FCGBP		1,1,1,2	NM_003890	534348 ⁵	BTA 18
134		45	101453_at	MIA		1,2,1,1	NM_006533	280857		·
135		45	102805_at	CEACAM1	***	1,2,2,1	NM_001712	404118
136		45	161825_f_a	CEACAM21	**	0,1,2,1	NM_033543	404118
137		49	95336_at	HIF3A		1,1,2,1	NM_152795	507699		·
138		50	95722_at	GLRX		1,1,2,1	NM_002064	515416
139		55-56	100325_at	LILRA2	*	1,1,1,2	NM_006866	533589 ⁵
140	19	0.01	101618_r_at	TP53		1,1,2,1	NM_000546	281542
141	(56)	13	160546_at	ALDOC		0,1,2,1	NM_005165	504584
142		14	96344_at	ENO3		2,1,0,1	NM_001976	540303
143		14	161947_f_at	ALOX12P2		1,2,1,1	XR_000632	282139
144		20	161408_r_at	DVL2		1,1,2,1	NM_004422	614312
145		28	161161_r_at	NME1		1,1,2,1	NM_000269	404079
146		28	160914_at	Wfdc12		1,2,1,1	NM_138684	615755
147		29	100091_at	SLC35B1		1,1,2,1	NM_005827	353217	BTA 19
148		37-38	161546_r_at	GRN		1,1,2,1	NM_001012479	NW_929519
149		38	161227_r_at	CNTD		0,1,2,1	NM_173478	539833
150		38	101484_at	NBR1		1,1,2,1	NM_005899	515032 ⁵		·
151		40	92391_at	CYB561		1,2,2,1	NM_001915	317663
152		45	161926_r_at	P4HB		1,2,2,1	NM_000918	281373
153		45	96943_at	GPS1		1,1,2,1	NM_004127	525572		·
154		49	99055_at	ST6GALNAC2		1,1,2,1	NM_006456	511690
155		51	101916_at	LLGL2		1,2,2,1	NM_001015002	539545
156	20	14-16	161280_r_at	PELO		1,1,2,1	NM_015946	528728 ⁵		··
157	(43)	21	98045_s_at	DAB2	**	1,1,2,1	NM_001343	509221	BTA 20	···
158		32	95518_at	FLJ20152		1,1,2,1	NM_019000	540068
159		36	93842_at	DAP	*	1,1,2,1	NM_004394	616066		·
160	21	14	92880_at	MFGE8	***	0,1,2,1	NM_005928	281913		··
161	(50)	14	103432_at	ISG20	**	1,1,2,1	NM_002201	506604	BTA 21	·
162		23	102407_at	CMA1		1,1,1,2	NM_001836	515720		·
163	22	10-11	160312_at	CMTM6	*	1,1,2,1	NM_017801	508881
164	(48)	10	104626_at	CMTM8		1,2,2,1	NM_178868	533671		·
165		12	161140_r_at	HSPD1		1,1,2,1	NM_002156	511913	BTA 22
166		42	101115_at	LTF	***	0,1,2,1	NM_002343	280846		·
167		44	95324_at	ATP2B2		1,1,2,1	NM_001001331	535048
168	23	0.005	102708_at ¹	BTN1A1	***	0,1,2,1	NM_001732	282157
169	(41)	0.1	160207_at	ACLY	*	1,1,2,1	NM_001096	511135		·
170		12-13	96828_at	GNMT	*	1,1,2,1	NM_018960	538212
171		22	93496_at	ELOVL5		1,1,2,1	NM_021814	617293
172		23	101421_at	TNXB		1,1,2,1	NM_032470	282654
173		23	103571_at	LST1		1,1,1,2	NM_007161	615744	BTA 23	·
174		23	93720_at	AGPAT1		1,1,2,1	NM_006411	282137
175		24	92715_at	UBD	*	1,2,1,1	NM_006398	513336 ⁵
176		25	101783_i_at	HIST1H3G		1,1,2,1	NM_003534	525511		·
177		31	92737_at	IRF4		2,1,0,1	NM_002460	506141 ⁵
178		31	161851_r_at	BPHL		1,1,2,1	NM_004332	505457
179	24	0.1	102335_at	KCNK1	**	1,2,2,1	NM_002245	505563
180	(45)	29	99994_at	CIDEA	***	1,1,2,1	NM_001279	527051		··
181		24-31	93316_at	OSBPL1A		1,1,2,1	NM_018030	505857 ⁵	BTA 24
182		42	103409_at	BAIAP2L1		1,2,2,1	NM_018842	615412
183		44	160270_at	LMAN1		1,1,2,1	NM_005570	511649		·
184	25	2	97987_at	IGFALS	**	1,1,2,1	NM_004970	532494
185	(41)	3	160275_at	SEPX1		1,1,2,1	NM_016332	618441
186		4	97228_at	ROGDI		1,2,2,1	NM_024589	510492
187		10	101534_at	TNP2		1,1,2,1	NM_005425	281538
188		18	104481_at	EEF2K	*	1,2,2,1	NM_013302	521730	BTA 25
189		24	95118_r_at	KIF22		1,2,1,1	NM_007317	506294
190		24	161120_r_at	TUFM		1,1,2,1	NM_003321	281556		·
191		30	94493_at	CLDN3	**	1,2,1,1	NM_001306	404153
192		30	103355_at	WBSCR21		0,1,2,1	AAS07472	510109
193	26	5	93100_at	ACTA2	**	1,2,1,1	NM_001613	515610
194	(36)	5-10	99541_at¹	KIF11		1,2,1,1	NM_004523	508467 ⁵		··
195		6	95738_at	ALDH18A1	*	1,1,2,1	NM_002860	514759
196		7	102123_at ¹	LIPA	**	0,1,2,1	NM_000235	536377	BTA 26
197		8-9	98295_at	Cyp2c39		1,1,2,1	NM_010003	540627		·
198		31	92554_at	CTBP2		1,2,1,1	NM_001329	281730
199		33	99457_at	MKI67	*	1,2,1,1	NM_002417	614894		·
200	29	1-2	101019_at	CTSC	*	1,1,2,1	NM_001814	352958
201	(46)	10	100389_at	COLQ		1,1,2,1	NM_005677	514615		··
202		21	93757_at	SRPR		1,1,2,1	NM_003139	NW_930736
203		31	160391_at	FADS1	**	0,1,2,1	NM_013402	533107	BTA 29
204		36	93618_at	SPTBN2		1,2,1,1	NM_006946	506239
205		36	95541_at	FAM3C		1,2,1,1	NM_001040020	615690
206		37	161615_f_at	MAP3K11		1,1,2,1	NM_002419	514210
207		62	160851_r_at	Cox8b		2,1,0,1	NM_007751	281091
208	X	19	97942_g_at	CAPN6		1,2,1,1	NM_014289	539360
209	(49)	21	93771_at	GJB1		1,1,2,1	NM_000166	281194
210		25	101464_at	TIMP1		1,1,2,1	NM_003254	282092
211		37	93495_at	PRDX4	*	0,1,2,1	NM_006406	281999
212		46	99034_at	IRX3	**	1,2,1,1	NM_024336	540417

Probe contains repeats

Lower case indicates MM RefSeq

Mammary specific score

Number of genes

Fold change
from median median

Score

3-10

10-30

>30

***

⁴

We coded the mean expression of a cluster at each stage as decrease, flat and Increase

and converted it to numerical representation as follows: "1" indicates no change between

0.5 and 2.0 fold change, and "0" and "2" indicate fold change <0.5 and >2 for down and up

regulation, respectively. Thus a unique array of four digits represents the

expression profile of each cluster along the developmental stages of puberty, pregnancy, lactation and involution.

⁵

Location determined according to adjacent genes

⁶

To relatively locate genes to the critical interval of the QTL, the alignment of the physical and the genetic maps was used: http://www.ncbi.nlm.nih.gov/mapview

⁷

QTL reports score

	Number of significant QTL reports	Score
	1-5	·
	6-10	··
	10<	···

For bugs reporting and feedback: M. Ron

Last update: August 1st, 2006.
Cite:
Ron, M., Israeli, G., Seroussi, E., Weller, J.I., Gregg, J.P., Shani, M., Medrano J.F. (2007)
Combining mouse mammary gland gene expression and comparative mapping for the identification
of candidate genes for QTL of milk production traits in cattle. BMC Genomics 8,183